Single-molecule dynamics and mechanisms of metalloregulators and metallochaperones.

نویسندگان

  • Peng Chen
  • Aaron M Keller
  • Chandra P Joshi
  • Danya J Martell
  • Nesha May Andoy
  • Jaime J Benítez
  • Tai-Yen Chen
  • Ace George Santiago
  • Feng Yang
چکیده

Understanding how cells regulate and transport metal ions is an important goal in the field of bioinorganic chemistry, a frontier research area that resides at the interface of chemistry and biology. This Current Topic reviews recent advances from the authors' group in using single-molecule fluorescence imaging techniques to identify the mechanisms of metal homeostatic proteins, including metalloregulators and metallochaperones. It emphasizes the novel mechanistic insights into how dynamic protein-DNA and protein-protein interactions offer efficient pathways via which MerR-family metalloregulators and copper chaperones can fulfill their functions. This work also summarizes other related single-molecule studies of bioinorganic systems and provides an outlook toward single-molecule imaging of metalloprotein functions in living cells.

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عنوان ژورنال:
  • Biochemistry

دوره 52 41  شماره 

صفحات  -

تاریخ انتشار 2013